L-dopa reverses behavioral deficits in the Pitx3 mouse fetus.
نویسندگان
چکیده
منابع مشابه
Gypenosides ameliorate memory deficits in MPTP-lesioned mouse model of Parkinson’s disease treated with L-DOPA
BACKGROUND Previous studies have revealed that gypenosides (GPS) improve the symptoms of anxiety disorders in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned rat model of Parkinson's disease (PD). The present study aimed to investigate the effects of GPS on memory deficits in an MPTP-lesioned mouse model of PD treated with L-3,4-dihydroxyphenylalanine (L-DOPA). METHODS MPTP (30...
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Midbrain dopamine (DA) neurons are involved in cognition, control of motor activity, and emotion-related behaviors. Degeneration of DA neurons particularly in the substantia nigra is a hallmark of Parkinson's disease. The homeobox transcription factor, Pitx3, plays a critical role in the development, function, and maintenance of midbrain DA neurons. We found that in young adult Pitx3-null mice,...
متن کاملL-dopa
Oleh Hornykiewicz was born in 1926 in Sykhiw, Poland (now Ukraine). In 1951, he received his M.D. degree from the University of Vienna and joined the faculty of his alma mater the same year and has worked there ever since. He also served for twenty years as chairman of the Institute of Biochemical Pharmacology. In 1967, he began a long association with the University of Toronto in Canada and, i...
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On the basis of comparison and analogy it can be stated. that in the mature fetus behavioral states comparable to those seen in the newborn infant, i.e. quiet sleep, active sleep and even some kind of wakefulness do exist (1). These states can be identified fairly well from heart rate and motor activity patterns. According to evaluation of 8 hour recordinqs of FHR and fetal movements in the fet...
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STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking, as well as ERK1/2, p38, Fyn, and Pyk2 activity. STEP is overactive in several neuropsychiatric and neurodegenerative disorders, including Alzheimer's disease (AD). The in...
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ژورنال
عنوان ژورنال: Behavioral Neuroscience
سال: 2014
ISSN: 1939-0084,0735-7044
DOI: 10.1037/bne0000016